INTRODUCTION
A recent paper by Wang and colleagues reported that patients with recent diagnosis of substance use disorder (SUD) had a greater risk for COVID-19.[1] The adjusted odds ratio was 8.699 with a 95% confidence interval (CI) of 8.411 to 8.997). Patients with opioid use disorder (OUD) were at the greatest risk.
The authors used a forest plot to summarize their findings (Figure 1). A forest plot is a diagram that displays the measurement of interest (e.g., odds ratio) with horizontal error bars to represent the 95% CI for several variables, which are aligned on the Y-axis. Forest plots are common in pair-wise meta-analysis where multiple studies are used to describe the effect size of the treatment versus the comparator group. Studies are arranged along the vertical axis and the odds ratio with 95% CI are displayed next to the studies. This allows the readers to see the effect size (e.g., odds ratio) and the uncertainty surrounding each study (or variable) in the meta-analysis.
Wang and colleague used this method to illustrate the odds of developing COVID-19 for different types of substance use disorders diagnosis along with their uncertainties. It’s an effective way to illustrate how much of a risk each SUD diagnosis category is associated with developing COVID-19.
Figure 1. Forest from the study that we will recreate.[1]*